Article
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.
Mechanisms of ageing and development - 1 Jan 2000
Moore Lynette, Lu Xiongbin, Ghebranious Nader, Tyner Stuart, Donehower Lawrence A
Abstract excerpt
Evidence has accumulated that p53, a prototypical tumor suppressor, may also influence aspects of organismal aging. We have previously described a p53 mutant mouse model, the p53+/m mouse, which is cancer resistant yet exhibits reduced longevity and premature aging phenotypes. p53+/m mice express one full length p53 allele and one truncated p53 allele that is translated into a C-terminal fragment of p53 termed...
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