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Article

Hematopoietic precursor cells within the yolk sac tumor component are the source of secondary hematopoietic malignancies in patients with mediastinal germ cell tumors

1 Mar 1994

Abstract excerpt

BACKGROUND: Patients with mediastinal germ cell tumors (MGCT) have a high incidence of hematologic malignancies unrelated to cytotoxic chemotherapy. It has been suggested that these leukemic conditions originate from a MGCT progenitor cell capable of undergoing non-germ cell (hematopoietic) differentiation. METHODS: To assess this hypothesis, histologic material from six patients with MGCTs associated with...

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PMID: 8111725
DOI: 10.1002/1097-0142(19940301)73:5<1535::aid-cncr2820730537>3.0.co;2-7

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