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Primary mediastinal germ cell tumor and clonally related and unique hematologic neoplasms with i(12p) and TP53 mutation: A report of two cases.

Annals of diagnostic pathology - 1 Aug 2022

Fang Hong, Toruner Gokce A, Tang Zhenya, Tang Guilin, Weissferdt Annikka, Tashakori Mehrnoosh, El Hussein Siba, Thakral Beenu, Quesada Andres E, Wang Wei, Patel Keyur P, Garcia-Manero Guillermo, Medeiros L Jeffrey, Bueso-Ramos Carlos E, Jelloul Fatima Zahra

Abstract excerpt

The development of clonally related hematologic neoplasms in the setting of primary mediastinal germ cell tumors (PMGCTs) has been recognized previously and is associated with a dismal prognosis. However, the presentation of hematologic neoplasms as chronic myelomonocytic leukemia (CMML) and hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Here we report two patients with PMGCTs and hematologic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35489185
DOI: 10.1016/j.anndiagpath.2022.151951

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