Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.

doi:10.1172/JCI139682

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Article

Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.

The Journal of clinical investigation - 1 Dec 2020

Taylor Justin, Donoghue Mark Ta, Ho Caleb, Petrova-Drus Kseniya, Al-Ahmadie Hikmat A, Funt Samuel A, Zhang Yanming, Aypar Umut, Rao Pavitra, Chavan Shweta S, Haddadin Michael, Tamari Roni, Giralt Sergio, Tallman Martin S, Rampal Raajit K, Baez Priscilla, Kappagantula Rajya, Kosuri Satyajit, Dogan Ahmet, Tickoo Satish K, Reuter Victor E, Bosl George J, Iacobuzio-Donahue Christine A, Solit David B, Taylor Barry S, Feldman Darren R, Abdel-Wahab Omar

Abstract excerpt

Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes. One in every 17 patients with primary mediastinal nonseminomatous GCTs develop an incurable hematologic malignancy and prior data intriguingly suggest a clonal relationship exists between hematologic malignancies and...

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Identifiers

PMID: 32897884
DOI: 10.1172/JCI139682
PMCID: PMC7685753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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