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Article

A link between c-Myc-mediated transcriptional repression and neoplastic transformation.

The Journal of clinical investigation - 1 Apr 1996

Lee L A, Dolde C, Barrett J, Wu C S, Dang C V

Abstract excerpt

Recent studies indicate that the transcription factor c-Myc contributes to oncogenesis by altering the expression of genes involved in cell proliferation, but its precise function in neoplasia remains ambiguous. The ability of c-Myc to bind the sequence CAC(G/A)TG and transactivate appears to be linked to its transforming activity; however, c-Myc also represses transcription in vitro through a pyrimidine-rich cis...

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Identifiers

PMID: 8601634
DOI: 10.1172/JCI118595
PMCID: PMC507233

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A link between c-Myc-mediated transcriptional repression and neoplastic transformation.PMID 8601634Read ↗

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