Article
A link between c-Myc-mediated transcriptional repression and neoplastic transformation.
The Journal of clinical investigation - 1 Apr 1996
Lee L A, Dolde C, Barrett J, Wu C S, Dang C V
Abstract excerpt
Recent studies indicate that the transcription factor c-Myc contributes to oncogenesis by altering the expression of genes involved in cell proliferation, but its precise function in neoplasia remains ambiguous. The ability of c-Myc to bind the sequence CAC(G/A)TG and transactivate appears to be...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Cell Transformation, Neoplastic
- DNA Primers
- Genes, myc
- Humans
- L Cells
- Lymphoma
- Mice
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Rats
- Transcription, Genetic
- Transfection