Article
DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II.
Nature - 6 Jan 1994
Guzder S N, Qiu H, Sommers C H, Sung P, Prakash L, Prakash S
Abstract excerpt
The RAD3 gene of Saccharomyces cerevisiae is required for excision repair of ultraviolet-damaged DNA and is essential for cell viability. The RAD3-encoded protein shares a high degree of homology with the human ERCC2(XPD) gene product. Mutations in XPD, besides causing the cancer-prone syndrome xeroderma pigmentosum, can also result in Cockayne's syndrome and trichothiodystrophy. To investigate the role of RAD3...
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