Article
A viable hypomorphic allele of the essential IMP3 gene reveals novel protein functions in Saccharomyces cerevisiae.
PloS one - 29 Apr 2011
Cosnier Bruno, Kwapisz Marta, Hatin Isabelle, Namy Olivier, Hermann-Le Denmat Sylvie, Morillon Antonin, Rousset Jean-Pierre, Fabret Céline
Abstract excerpt
In Saccharomyces cerevisiae, the essential IMP3 gene encodes a component of the SSU processome, a large ribonucleoprotein complex required for processing of small ribosomal subunit RNA precursors. Mutation of the IMP3 termination codon to a sense codon resulted in a viable mutant allele producing a C-terminal elongated form of the Imp3 protein. A strain expressing the mutant allele displayed ribosome biogenesis...
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