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Article

Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast.

Nature - 3 Mar 1994

Wang Z, Svejstrup J Q, Feaver W J, Wu X, Kornberg R D, Friedberg E C

Abstract excerpt

Nucleotide-excision repair (NER) is an important cellular defence mechanism against mutagenesis and carcinogenesis. The essential yeast genes RAD3 (ref. 2) and SSL2 (RAD25), homologues of the human xeroderma pigmentosum genes XPD and XPB respectively, have been implicated in NER in yeast. The products of these genes are also subunits of (Rad3 protein) or associate with (Ssl2 protein) purified yeast RNA polymerase...

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PMID: 8107888
DOI: 10.1038/368074a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast.PMID 8107888Read ↗

The Role of TFIIH Complex in Nucleotide Excision RepairSemantic proximity Read ↗

The role of Transcription Factor IIH complex in nucleotide excision repairSemantic proximity Read ↗

DNA repair deficiencies associated with mutations in genes encoding subunits of transcription initiation factor TFIIH in yeast.Semantic proximity Read ↗

The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription.Semantic proximity Read ↗

A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and TranscriptionSemantic proximity Read ↗

Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair.Semantic proximity Read ↗

Replication fork breakage and re-start: New insights into Rad3/XPD-associated deficiencies.Semantic proximity Read ↗

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.Semantic proximity Read ↗

The histone variant H2A.Z is required for efficient transcription-coupled NER and to maintain genome integrity in UV challenged yeast cellsSemantic proximity Read ↗

Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.Semantic proximity Read ↗

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.Semantic proximity Read ↗

An interaction between the Tfb1 and Ssl1 subunits of yeast TFIIH correlates with DNA repair activity.Semantic proximity Read ↗

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