Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain.

Journal of virology - 1 Mar 1994

Ramakrishnan R, Fink D J, Jiang G, Desai P, Glorioso J C, Levine M

Abstract excerpt

Competitive quantitative PCRs were used to examine the consequences of stereotactically injecting a highly attenuated herpes simplex virus type 1 mutant into rat brains. This mutant virus, designated RR1CAT/RR2lacZ, was engineered so that coding sequences of the genes UL39 and UL40 specifying the subunits of the viral ribonucleotide reductase were replaced by the chloramphenicol acetyltransferase (CAT) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to RNA, Messenger

Share to RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 8107247
DOI: 10.1128/JVI.68.3.1864-1873.1994
PMCID: PMC236649

Genes

LAT
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain.PMID 8107247Read ↗

PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant.Semantic proximity Read ↗

Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain TissueSemantic proximity Read ↗

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.Semantic proximity Read ↗

The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latencySemantic proximity Read ↗

Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.Semantic proximity Read ↗

In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal gangliaof latently infected miceSemantic proximity Read ↗

Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.Semantic proximity Read ↗

In vivo characterization of site-directed mutations in the promoter of the herpes simplex virus type 1 latency-associated transcriptsSemantic proximity Read ↗

In vivo expression of beta-galactosidase in hippocampal neurons by HSV-mediated gene transfer.Semantic proximity Read ↗

Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1.Semantic proximity Read ↗

Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype.Semantic proximity Read ↗

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.