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Article

Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.

Journal of virology - 1 Dec 1993

Nicosia M, Deshmane S L, Zabolotny J M, Valyi-Nagy T, Fraser N W

Abstract excerpt

The results of studies in several laboratories suggest that a TATA box-containing promoter located in the herpes simplex virus type 1 internal long repeat and long terminal repeat elements drives expression of the latency-associated transcripts (LATs). In the present study, we show that expression of a 2-kb LAT-related transcript can occur in the absence of this LAT TATA promoter, indicating the existence of a...

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Source

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Identifiers

PMID: 8230451
DOI: 10.1128/JVI.67.12.7276-7283.1993
PMCID: PMC238191

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region.PMID 8230451Read ↗

Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection.Semantic proximity Read ↗

The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latencySemantic proximity Read ↗

A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics.Semantic proximity Read ↗

The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosineSemantic proximity Read ↗

Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit ApoptosisSemantic proximity Read ↗

Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.Semantic proximity Read ↗

The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.Semantic proximity Read ↗

A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation.Semantic proximity Read ↗

Expression of the herpes simplex virus type 1 latency-associated transcripts does not influence latency establishment of virus mutants deficient for neuronal replication.Semantic proximity Read ↗

Herpes simplex virus latency-associated transcript is a stable intron.Semantic proximity Read ↗

A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.Semantic proximity Read ↗

A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivationSemantic proximity Read ↗

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