In vivo expression of beta-galactosidase in hippocampal neurons by HSV-mediated gene transfer.

doi:10.1089/hum.1992.3.1-11

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In vivo expression of beta-galactosidase in hippocampal neurons by HSV-mediated gene transfer.

Human gene therapy - 1 Feb 1992

Fink D J, Sternberg L R, Weber P C, Mata M, Goins W F, Glorioso J C

Abstract excerpt

Stereotactic inoculation of a herpes simplex virus (HSV) gene transfer vector into the hippocampus and caudate of rat brain resulted in limited and transient viral replication and the establishment of latency. Virus attenuation was achieved by insertional inactivation of a viral gene, Us3. Insert...

Topics

Animals
Base Sequence
DNA, Recombinant
Gene Expression
Genetic Vectors
Hippocampus
Immunohistochemistry
Lac Operon
Male
Molecular Sequence Data
Mutation
Neurons
Polymerase Chain Reaction
Protein Kinases
Rats
Rats, Inbred Strains
Simplexvirus
Transfection

Source

Open in PubMed

Identifiers

PMID: 1314100
DOI: 10.1089/hum.1992.3.1-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1314100-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics