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Article

In vivo expression of beta-galactosidase in hippocampal neurons by HSV-mediated gene transfer.

Human gene therapy - 1 Feb 1992

Fink D J, Sternberg L R, Weber P C, Mata M, Goins W F, Glorioso J C

Abstract excerpt

Stereotactic inoculation of a herpes simplex virus (HSV) gene transfer vector into the hippocampus and caudate of rat brain resulted in limited and transient viral replication and the establishment of latency. Virus attenuation was achieved by insertional inactivation of a viral gene, Us3. Insertion of a lacZ reporter gene, under the control of the HSV glycoprotein C (gC) late gene promoter, allowed viral...

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Identifiers

PMID: 1314100
DOI: 10.1089/hum.1992.3.1-11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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