Article
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Cancer research - 1 Apr 2001
Jacobs A, Tjuvajev J G, Dubrovin M, Akhurst T, Balatoni J, Beattie B, Joshi R, Finn R, Larson S M, Herrlinger U, Pechan P A, Chiocca E A, Breakefield X O, Blasberg R G
Abstract excerpt
To evaluate the efficiency of gene delivery in gene therapy strategies for malignant brain tumors, it is important to determine the distribution and magnitude of transgene expression in target tumor cells over time. Here, we assess the time- and vector dose-dependent kinetics of recombinant herpes simplex virus (HSV)-1 vector-mediated gene expression and vector replication in culture and in vivo by a recently...
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