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Article

Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis

1 Apr 1996

Abstract excerpt

Disruption of the murine mdr2 (multidrug-resistance) gene, which encodes a phosphatidylcholine flippase, leads to a hepatic disorder because of loss of biliary phospholipid secretion. Among the hereditary human cholestasis, a subtype of progressive familial intrahepatic cholestasis with high gamma-glutamyltranspeptidase (GGT) serum activity shares histological, biochemical, and genetic features with mice lacking...

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Identifiers

PMID: 8666348
DOI: 10.1002/hep.510230435

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