Article
Liver diseases related to MDR3 (ABCB4) gene deficiency.
Frontiers in bioscience (Landmark edition) - 1 Jan 2009
Gonzales Emmanuel, Davit-Spraul Anne, Baussan Christiane, Buffet Catherine, Maurice Michele, Jacquemin Emmanuel
Abstract excerpt
Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- Animals
- Biliary Tract
- Genotype
- Humans
- Liver Diseases
- Mice
- Mice, Knockout
- Phenotype
- Phospholipids