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Article

Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseases.

Seminars in liver disease - 1 Nov 2001

Jacquemin E

Abstract excerpt

Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in humans, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion. The role of an MDR3 gene defect in liver disease was initially suspected in a subtype of progressive familial intrahepatic cholestasis called PFIC3. Several MDR3 mutations have been identified in children with PFIC3 and are...

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Identifiers

PMID: 11745043
DOI: 10.1055/s-2001-19033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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