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Article

Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.

The Journal of clinical investigation - 1 Jan 1995

Oude Elferink R P, Ottenhoff R, van Wijland M, Smit J J, Schinkel A H, Groen A K

Abstract excerpt

Disruption of the mdr2 gene in mice leads to a complete absence of phospholipid from bile (Smit, J. J. M., et al. 1993. Cell. 75:451-462). We have investigated the control of both mdr2 P-glycoprotein (Pgp) expression and bile salt secretion on biliary lipid secretion in the mouse. Lipid secretion...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Bile
Bile Acids and Salts
Catheterization
Cholesterol
Gallbladder
Genotype
Heterozygote
Homozygote
Liver
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mutation

Phospholipids

Taurocholic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7814632
DOI: 10.1172/JCI117658
PMCID: PMC295363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7814632-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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