Article
Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.
The Journal of clinical investigation - 1 Jan 1995
Oude Elferink R P, Ottenhoff R, van Wijland M, Smit J J, Schinkel A H, Groen A K
Abstract excerpt
Disruption of the mdr2 gene in mice leads to a complete absence of phospholipid from bile (Smit, J. J. M., et al. 1993. Cell. 75:451-462). We have investigated the control of both mdr2 P-glycoprotein (Pgp) expression and bile salt secretion on biliary lipid secretion in the mouse. Lipid secretion was monitored at various bile salt output rates in wild-type mice (+/+), heterozygotes (+/-), and homozygotes (-/-)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.