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Article

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.

The Journal of biological chemistry - 27 Sept 2013

Cetinbas Naniye, Huang-Hobbs Helen, Tognon Cristina, Leprivier Gabriel, An Jianghong, McKinney Steven, Bowden Mary, Chow Connie, Gleave Martin, McIntosh Lawrence P, Sorensen Poul H

Abstract excerpt

The ETV6-NTRK3 (EN) chimeric oncogene is expressed in diverse tumor types. EN is generated by a t(12;15) translocation, which fuses the N-terminal SAM (sterile α-motif) domain of the ETV6 (or TEL) transcription factor to the C-terminal PTK (protein-tyrosine kinase) domain of the neurotrophin-3 receptor NTRK3. SAM domain-mediated polymerization of EN leads to constitutive activation of the PTK domain and...

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Identifiers

PMID: 23798677
DOI: 10.1074/jbc.M113.475301
PMCID: PMC3784708

Genes

ETV6
NTRK3

Provenance

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