Article
Biochemical and cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. VI. The correlation between UV-induced DNA lesions and chromosomal aberrations, and their modulations with inhibitors of DNA repair synthesis.
Mutation research - 1 Mar 1990
Darroudi F, Natarajan A T, van der Schans G P
Abstract excerpt
The role of UV-induced DNA lesions and their repair in the formation of chromosomal aberrations in the xrs mutant cell lines xrs 5 and xrs 6 and their wild-type counterpart, CHO-K1 cells, were studied. The extent of induction of DNA single-strand breaks (SSBs) and DNA double-strand breaks (DSBs) due to UV irradiation in the presence or absence of 1-beta-D-arabinofuranosylcytosine (ara-C) and hydroxyurea (HU) was...
Topics
- Animals
- Cell Line
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Cytarabine
- DNA
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Single-Stranded