Article
Effects of hyperthermia on the repair of radiation-induced DNA single- and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000
Iliakis G, Seaner R, Okayasu R
Abstract excerpt
The effect of heat on the induction and repair of DNA single (ssb) and double (dsb) strand breaks was studied in irradiated exponentially growing or plateau-phase CHO cells and their DNA dsb repair-deficient, radiation-sensitive counterpart, the xrs-5 cells. Induction and repair of DNA ssb was me...
Topics
- Animals
- Cell Cycle
- Cell Division
- Cell Line
- DNA Damage
- DNA Repair
- DNA, Single-Stranded
- Dose-Response Relationship, Radiation
- Hot Temperature
- Kinetics
- Mutation
- Radiation Tolerance