Article
Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers.
Human heredity - 1 Jan 2000
O'Hara B F, Smith S S, Bird G, Persico A M, Suarez B K, Cutting G R, Uhl G R
Abstract excerpt
Alleles of the dopamine D2 receptor gene are distinguished by polymorphic A and B TaqI sites approximately 10 kb 3' to the final exon and bordering the second exon, respectively. These alleles have been reported to be more prevalent in heavy substance users than in control populations in several, although not all studies. Meta-analyses of combined data from available work support significant association. Two...
Topics
- Alleles
- Black People
- Blotting, Southern
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Gene Frequency
- Genetic Markers
- Haplotypes
- Humans
- Linkage Disequilibrium
- Nucleic Acid Hybridization