Article
Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers.
Archives of general psychiatry - 1 Sept 1992
Smith S S, O'Hara B F, Persico A M, Gorelick D A, Newlin D B, Vlahov D, Solomon L, Pickens R, Uhl G R
Abstract excerpt
Alcoholics are more likely than nonalcoholics to display the Taq I A1 restriction fragment length polymorphism of the D2 dopamine receptor gene, according to four of six studies that examined alcoholics and controls. The current study examines whether the association observed in alcoholism might extend to other addictive substances by examining D2 dopamine receptor Taq I A and B restriction fragment length...
Topics
- Alcoholism
- Alleles
- Female
- Genetic Markers
- Humans
- Male
- Polymorphism, Restriction Fragment Length
- Receptors, Dopamine
- Substance-Related Disorders