Article
Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism.
Alcohol (Fayetteville, N.Y.) - 1 Jan 2000
Blum K, Noble E P, Sheridan P J, Finley O, Montgomery A, Ritchie T, Ozkaragoz T, Fitch R J, Sadlack F, Sheffield D
Abstract excerpt
In a blinded study, 159 subjects composed of nonalcoholics (N = 43), less severe alcoholics (N = 44), severe alcoholics (N = 52) and young children of alcoholics (CoAs, N = 20) were studied for their allelic association with the D2 dopamine receptor (D2DR) gene utilizing peripheral lymphocytes as the DNA source. The combined alcoholic group compared to the nonalcoholic group showed a significantly greater...
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