Article
Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse.
Drug and alcohol dependence - 1 Feb 1993
Persico A M, O'Hara B F, Farmer S, Gysin R, Flanagan S D, Uhl G R
Abstract excerpt
The D2 dopamine receptor gene (DRD2) displays Taq I restriction fragment length polymorphisms (RFLPs) at two different loci, termed A and B. One of the three different Taq I A 'alleles' described at this site, the A1 allele (size = 6.6 kb), has been found to be associated with alcoholism and with drug abuse in the majority of studies reported to date. A complete map of the Taq I A RFLP site has been constructed,...
Topics
- Alcoholism
- Alleles
- Chromosome Mapping
- DNA Probes
- DNA-Directed DNA Polymerase
- Humans
- Illicit Drugs
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Psychotropic Drugs