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Article

Intratumor Heterogeneity of Homologous Recombination Deficiency in Primary Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2017

von Wahlde Marie-Kristin, Timms Kirsten M, Chagpar Anees, Wali Vikram B, Jiang Tingting, Bossuyt Veerle, Saglam Ozlen, Reid Julia, Gutin Alexander, Neff Chris, Lanchbury Jerry S, Hatzis Christos, Hofstatter Erin, Pusztai Lajos

Abstract excerpt

Purpose: The 3-biomarker homologous recombination deficiency (HRD) assay measures the number of telomeric allelic imbalances, loss of heterozygosity, and large-scale state transitions in tumor DNA and combines these metrics into a single score that reflects DNA repair deficiency. The goal of this study is to assess the consistency of these HRD measures in different biopsies from distinct areas of the same...

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Share to Allelic Imbalance
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Loss of Heterozygosity

Share to Receptor, ErbB-2

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Source

Identifiers

PMID: 27601588
DOI: 10.1158/1078-0432.CCR-16-0889

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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