Article
Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers.
Cytometry - 15 Jun 2001
Janocko L E, Brown K A, Smith C A, Gu L P, Pollice A A, Singh S G, Julian T, Wolmark N, Sweeney L, Silverman J F, Shackney S E
Abstract excerpt
BACKGROUND: Human solid tumors undergo clonal evolution as they progress, but evidence for specific sequences of genetic changes that occur in individual tumors and are recapitulated in other tumors is difficult to obtain. METHODS: Patterns of amplification of Her-2/neu, c-myc, and cyclin D1 were determined by fluorescence in situ hybridization (FISH) in relation to the presence of p53 dysfunction and ploidy in...
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