Article
The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth.
Gene - 17 Oct 2001
Cadwell C, Zambetti G P
Abstract excerpt
The tumor suppressor p53 plays a central role in the protection against DNA damage and other forms of physiological stress primarily by inducing cell cycle arrest or apoptosis. Mutation of p53, which is the most frequent genetic alteration detected in human cancers, inactivates these growth regulatory functions and causes a loss of tumor suppressor activity. In some cases, mutation also confers tumor-promoting...
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