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Article

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

Nucleic acids research - 1 Jan 2007

Vikhanskaya Faina, Lee Ming Kei, Mazzoletti Marco, Broggini Massimo, Sabapathy Kanaga

Abstract excerpt

Tumour-derived p53 mutants are thought to have acquired 'gain-of-function' properties that contribute to oncogenicity. We have tested the hypothesis that p53 mutants suppress p53-target gene expression, leading to enhanced cellular growth. Silencing of mutant p53 expression in several human cell lines was found to lead to the upregulation of wild-type p53-target genes such as p21, gadd45, PERP and PTEN. The...

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Source

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Identifiers

PMID: 17344317
DOI: 10.1093/nar/gkm099
PMCID: PMC1874625

Genes

PERP
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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