Article
Antisense epidermal growth factor receptor (EGFR) transfection down-regulates EGFR expression and suppresses the malignant phenotype of human nasopharyngeal carcinoma CNE-2 cell line.
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA - 1 Sept 2003
Deng Fan, Wang Yu, Zeng Fang-yin, Zou Zhi-peng, Bai Xiao-chun, Lu Di, Ke Zhi-yong, Luo Shen-qiu
Abstract excerpt
OBJECTIVE: To determine whether epidermal growth factor receptor (EGFR) expression contributes to tumor growth of poorly differentiated human nasopharyngeal carcinoma CNE-2 cell lines. METHODS: An expression vector containing a N-terminal fragment (1.35 kb) of human EGFR in the antisense orientation was transfected into CNE-2 cell lines via lipofectamine. The established clones resistant to G418 were isolated and...
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