Article
Genomic imprinting and cancer.
Cancer surveys - 1 Jan 1995
Brenton J D, Viville S, Surani M A
Abstract excerpt
Imprinting is vital for normal development, and disruption of imprinting mechanisms on syntenic chromosomes gives very similar phenotypes in mouse and humans. In addition, disruption of normal imprinting provides a plausible explanation for preferential LOH in some embryonal tumours. Moreover, there is evidence that in Wilms' tumour, dysregulation of specific imprinted genes may give rise to the cancer phenotype....
Topics
- Alleles
- Aneuploidy
- Animals
- Beckwith-Wiedemann Syndrome
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human
- Genomic Imprinting
- Humans
- Mice
- Neoplasms
- Species Specificity