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Article

A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.

The Journal of cell biology - 1 Aug 1991

Brewer C B, Roth M G

Abstract excerpt

In the polarized kidney cell line MDCK, the influenza virus hemagglutinin (HA) has been well characterized as a model for apically sorted membrane glycoproteins. Previous work from our laboratory has shown that a single amino acid change in the cytoplasmic sequence of HA converts it from a protein that is excluded from coated pits to one that is efficiently internalized. Using trypsin or antibodies to mark...

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Identifiers

PMID: 1860878
DOI: 10.1083/jcb.114.3.413
PMCID: PMC2289095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin.PMID 1860878Read ↗

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Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.Semantic proximity Read ↗

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