Degradation of mutant influenza virus hemagglutinins is influenced by cytoplasmic sequences independent of internalization signals.

doi:10.1074/jbc.271.2.907

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Article

Degradation of mutant influenza virus hemagglutinins is influenced by cytoplasmic sequences independent of internalization signals.

The Journal of biological chemistry - 12 Jan 1996

Zwart D E, Brewer C B, Lazarovits J, Henis Y I, Roth M G

Abstract excerpt

A mutant influenza virus hemagglutinin, HA+8, having a carboxyl-terminal extension of 8 amino acids that included 4 aromatic residues, was internalized within 2 min of arriving at the cell surface and was degraded quickly by a process that was inhibited by ammonium chloride. Through second-site m...

Topics

Amino Acid Sequence
Biological Transport
Cell Membrane
Cytoplasm
Hemagglutinins
Molecular Sequence Data
Mutation
Orthomyxoviridae

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