Article
Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein.
Gene therapy - 1 Jan 1999
Vinyals A, Peinado M A, Gonzalez-Garrigues M, Monzó M, Bonfil R D, Fabra A
Abstract excerpt
The introduction of exogenous wild-type p53 into human cancer cells bearing p53 mutation does not necessarily result in inhibition of tumor growth. We have demonstrated this in MDA-MB468 breast cancer cells which are hemizygous for p53 mutation and also in KM12SM colorectal carcinoma cells which are heterozygous for p53 mutation. The wtp53 transfectants decreased three- to four-fold the number of colonies...
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