The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

doi:10.1101/gad.5.3.358

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Article

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

Genes & development - 1 Mar 1991

Kamps M P, Look A T, Baltimore D

Abstract excerpt

The t(1;19) translocation that characterizes 25% of pediatric pre-B cell acute lymphoblastic leukemias (pre-B ALL) produces a chimeric gene, joining 5' sequences that encode a transcriptional activator domain of E2A with 3' sequences that, in part, encode a homeo box domain of a new gene called pbx1. Two E2A-pbx1 transcripts have been cloned. They encode the putative fusion proteins, p85(E2A-Pbx1) and...

Topics

Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Chimera
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 19
Genes, Homeobox
Homeodomain Proteins
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Oncogene Proteins, Fusion

Precipitin Tests

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 1672117
DOI: 10.1101/gad.5.3.358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1672117-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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