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Article

Site-specific translocation and evidence of postnatal origin of the t(1;19) <i>E2A-PBX1</i> fusion in childhood acute lymphoblastic leukemia

1 Nov 2002

Abstract excerpt

The t(1;19) translocation yields a fusion between E2A and PBX1 genes and occurs in 5% of acute lymphoblastic leukemia in children and adults. We used chromosomal translocations and Ig heavy chain (IGH)/T cell antigen receptor (TCR) rearrangements to develop an understanding of the etiology and natural history of this subtype of leukemia. We sequenced the genomic fusion between E2A and PBX1 in 22 preB acute...

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Identifiers

PMID: 12415113
DOI: 10.1073/pnas.222481199

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