Article
Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency.
EMBO reports - 1 Dec 2003
Bechter Oliver E, Zou Ying, Shay Jerry W, Wright Woodring E
Abstract excerpt
Homologous recombination is thought to be the molecular mechanism for maintaining telomere length in alternative lengthening of telomeres (ALT) cells. We used a recombination reporter system to show that the frequency of homologous recombination is the same for ALT- and telomerase-positive cells, suggesting that if ALT cells have a recombination defect it specifically involves telomeric sequences. We compared...
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