Article
The human telomere and its relationship to human disease, therapy, and tissue engineering.
Frontiers in bioscience : a journal and virtual library - 1 May 2007
Moon Ian K, Jarstfer Michael B
Abstract excerpt
The chromosomes of eukaryotes end in a specialized complex of proteins and repetitive DNA called the telomere. Telomeres form a protective cap that prevents chromosome fusions, protects chromosome ends from degradation, and assists in positioning chromosomes in the nucleus. In the absence of replenishing mechanisms, telomeric DNA is lost during each cell cycle owing to incomplete replication, oxidative damage,...
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