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Article

Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.

Cell reports - 23 Feb 2012

Taboski Michael A S, Sealey David C F, Dorrens Jennifer, Tayade Chandrakant, Betts Dean H, Harrington Lea

Abstract excerpt

Despite the importance of telomere maintenance in cancer cell survival via the elongation of telomeres by telomerase reverse transcriptase (TERT) or alternative lengthening of telomeres (ALT), it had not been tested directly whether telomere maintenance is dispensable for human tumorigenesis. We engineered human tumor cells containing loxP-flanked hTERT to enable extensive telomere elongation prior to complete...

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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22832159
DOI: 10.1016/j.celrep.2011.12.004
PMCID: PMC3406325

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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