Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

Abstract excerpt

With the aim of establishing whether a genetically reduced capability of producing apolipoprotein E (apo E) can affect atherogenesis, we have compared the consequences of dietary stress on normal mice and on mice heterozygous or homozygous for a disrupted apo E gene. A dramatically accelerated development of lesions occurred in the vasculature of the homozygous mutants as a result of feeding an atherogenic diet...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipokines, Inflammation, and Metabolic Diseases
• Share to Antioxidant Activity and Oxidative Stress
• Share to Atherosclerosis and Cardiovascular Diseases