Article
The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.
The Journal of biological chemistry - 16 Sept 1994
Zwerschke W, Rottjakob H W, Küntzel H
Abstract excerpt
We have compared the periodic fluctuation of mRNAs encoded by CDC6, a cell cycle gene controlling initiation of DNA replication, and CLN1, a G1 cyclin gene expressed at late G1. The maxima of CDC6 mRNA precede those of CLN1 mRNA by about 15 min in cells synchronized by release from pheromone arrest or from a cdc15 thermal arrest. CDC6 mRNA accumulates in cdc15-arrested telophase cells, decays around cell...
Topics
- Adenosine Triphosphatases
- Cell Cycle Proteins
- Cyclins
- Fungal Proteins
- GTP Phosphohydrolases
- Genes, Fungal
- Mitosis
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- S Phase
