Article

Optimizing histatin 5: Effects of K13 and K17 substitutions on proteolytic stability and antifungal activity

2026-01-31

Abstract excerpt

Candida albicans is an opportunistic human fungal pathogen found in the oral cavity. Human saliva contains a 24-amino acid peptide called histatin 5 (Hst5) that has activity against C. albicans , but degradation of Hst5 by secreted aspartyl proteases (Saps) produced by C. albicans and by salivary proteases can reduce its antifungal efficacy. Building on our previous work that identified K13 and K17 as important...

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Literature Corpus work: 8ab4cb5e-ae53-5335-9480-66466d57e491
DOI: 10.64898/2026.01.31.703050

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