Article
Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts.
Journal of cell science - 15 Nov 2012
Devrekanli Asli, Foltman Magdalena, Roncero Cesar, Sanchez-Diaz Alberto, Labib Karim
Abstract excerpt
The chitin synthase that makes the primary septum during cell division in budding yeasts is an important therapeutic target with an unknown activation mechanism. We previously found that the C2-domain of the Saccharomyces cerevisiae Inn1 protein plays an essential but uncharacterised role at the cleavage site during cytokinesis. By combining a novel degron allele of INN1 with a point mutation in the C2-domain, we...
Topics
- Alleles
- Amino Acid Sequence
- Biocatalysis
- Cell Cycle Proteins
- Cell Proliferation
- Chitin Synthase
- Cytokinesis
- Genes, Dominant
- Genes, Fungal
- Genes, Suppressor
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutant Proteins
- Mutation