Article
Chitin synthetase mutants of Phycomyces blakesleeanus.
Molecular & general genetics : MGG - 1 Jul 1993
Cubero B, Ruiz-Herrera J, Cerdá-Olmedo E
Abstract excerpt
Mutants resistant to nikkomycin, an inhibitor of chitin biosynthesis, were isolated after exposure of wild-type spores of the fungus Phycomyces blakesleeanus to N-methyl-N'-nitro-N-nitrosoguanidine. Genetic analysis revealed that nikkomycin resistance was due to mutations in a single gene, chsA. Mutants and wild type grew equally well in the absence of nikkomycin. In contrast to the wild type, whose spore...
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