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Article

Two mutants selectively resistant to polyenes reveal distinct mechanisms of antifungal activity by nystatin and amphotericin B.

Biochemical Society transactions - 1 Nov 2005

Hapala I, Klobucníková V, Mazánová K, Kohút P

Abstract excerpt

Polyene macrolides nystatin and amphotericin B are widely used in the treatment of fungal infections. In order to characterize factors affecting polyene activity, we have isolated Saccharomyces cerevisiae mutants showing selective resistance to nystatin and amphotericin B. Characterization of two of these mutants (nystatin-resistant mutant X1/16 and amphotericin B-resistant mutant X3/33) is presented. Genetic...

Topics

Amphotericin B
Antifungal Agents
Drug Resistance, Fungal
Microbial Sensitivity Tests
Nystatin
Phenotype
Saccharomyces cerevisiae

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16246082
DOI: 10.1042/BST20051206

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