Selective incorporation of fibronectin isoforms into the extracellular matrix of hybrids between human fibrosarcoma cells and normal human fibroblasts.

Abstract excerpt

A matched pair of tumorigenic and nontumorigenic human hybrids between GM0097 diploid fibroblasts and HT1080 fibrosarcoma cells was used to investigate further the relationship between the amount of surface fibronectin and the malignant potential of the cell. We can confirm that the malignant phenotype in these hybrids cosegregates with a decrease in cell-surface fibronectin. Moreover, the nontumorigenic hybrid...

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