Article
Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells.
PloS one - 1 Jan 2013
Castoria Gabriella, Giovannelli Pia, Di Donato Marzia, Hayashi Ryo, Arra Claudio, Appella Ettore, Auricchio Ferdinando, Migliaccio Antimo
Abstract excerpt
BACKGROUND: Hormones and growth factors influence the proliferation and invasiveness of human mesenchymal tumors. The highly aggressive human fibrosarcoma HT1080 cell line harbors classical androgen receptor (AR) that responds to androgens triggering cell migration in the absence of significant mitogenesis. As occurs in many human cancer cells, HT1080 cells also express epidermal growth factor receptor (EGFR)....
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