Article
Tumour cell hybridization and metastasis revisited.
Melanoma research - 1 Dec 2000
Pawelek J M
Abstract excerpt
This article reviews a long-standing hypothesis that metastases might be initiated through the generation of hybrids between primary tumour cells and tumour-infiltrating leucocytes such as macrophages. In this concept the hybrids become metastatic through expression of the leucocyte motility phenotype. A history of the hybrid hypothesis is presented along with recent evidence on how macrophage x tumour cell...
Topics
- Aneuploidy
- Animals
- Apoptosis
- Cell Movement
- Gene Expression Regulation, Neoplastic
- Glycosylation
- Humans
- Hybrid Cells
- Hybridization, Genetic
- Macrophages
- Mice
- Neoplasm Metastasis
- Neoplasms
- Phenotype