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Article

Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization.

The American journal of physiology - 1 Oct 1993

Geering K, Jaunin P, Jaisser F, Mérillat A M, Horisberger J D, Mathews P M, Lemas V, Fambrough D M, Rossier B C

Abstract excerpt

A highly conserved sequence motif (4 tyrosines and 1 proline: YYPYY) of the Na(+)-K(+)-adenosinetriphosphatase (ATPase) beta 1-subunit ectodomain has been mutagenized to study its possible role in alpha/beta-assembly and sodium pump function. Single as well as double tyrosine mutants (tyrosine to phenylalanine: Y to F) of Xenopus laevis beta 1-subunits are able to associate with alpha 1-subunits and form...

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PMID: 8238307
DOI: 10.1152/ajpcell.1993.265.4.C1169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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