Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization.

doi:10.1152/ajpcell.1993.265.4.C1169

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Article

Mutation of a conserved proline residue in the beta-subunit ectodomain prevents Na(+)-K(+)-ATPase oligomerization.

The American journal of physiology - 1 Oct 1993

Geering K, Jaunin P, Jaisser F, Mérillat A M, Horisberger J D, Mathews P M, Lemas V, Fambrough D M, Rossier B C

Abstract excerpt

A highly conserved sequence motif (4 tyrosines and 1 proline: YYPYY) of the Na(+)-K(+)-adenosinetriphosphatase (ATPase) beta 1-subunit ectodomain has been mutagenized to study its possible role in alpha/beta-assembly and sodium pump function. Single as well as double tyrosine mutants (tyrosine to...

Topics

Animals
Biological Transport
Cell Membrane
Mutation
Oocytes
Peptide Fragments
Proline
Sodium-Potassium-Exchanging ATPase
Xenopus laevis

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