Genomic scan for genes predisposing to schizophrenia.

doi:10.1002/ajmg.1320540111

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Article

Genomic scan for genes predisposing to schizophrenia.

American journal of medical genetics - 15 Mar 1994

Coon H, Jensen S, Holik J, Hoff M, Myles-Worsley M, Reimherr F, Wender P, Waldo M, Freedman R, Leppert M

Abstract excerpt

We initiated a genome-wide search for genes predisposing to schizophrenia by ascertaining 9 families, each containing three to five cases of schizophrenia. The 9 pedigrees were initially genotyped with 329 polymorphic DNA loci distributed throughout the genome. Assuming either autosomal dominant or recessive inheritance, 254 DNA loci yielded lod scores less than -2.0 at theta = 0.0, 101 DNA markers gave lod...

Topics

Adolescent
Adult
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 4
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lod Score

Male

Models, Genetic

Polymorphism, Restriction Fragment Length

Repetitive Sequences, Nucleic Acid

Restriction Mapping

Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 7909992
DOI: 10.1002/ajmg.1320540111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7909992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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