Article
Neural induction and patterning in the mouse in the absence of the node and its derivatives.
Developmental biology - 15 Dec 1999
Klingensmith J, Ang S L, Bachiller D, Rossant J
Abstract excerpt
The signals which induce vertebrate neural tissue and pattern it along the anterior-posterior (A-P) axis have been proposed to emanate from Spemann's organizer, which in mammals is a structure termed the node. However, mouse embryos mutant for HNF3 beta lack a morphological node and node derivatives yet undergo neural induction. Gene expression domains occur at their normal A-P axial positions along the mutant...
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