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Article

Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Oct 2021

Toldi Vanda, Kassay Norbert, Szabó András

Abstract excerpt

BACKGROUND/OBJECTIVE: Mutation-induced misfolding of digestive enzymes has been shown to cause chronic pancreatitis. Recently, heterozygous pancreatic lipase (PNLIP) mutations leading to reduced secretion were identified. The aim of the present study was to investigate whether PNLIP mutants with a secretion defect result in endoplasmic reticulum (ER) stress in cell culture models. METHODS: We introduced the...

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Identifiers

PMID: 34373204
DOI: 10.1016/j.pan.2021.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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